Turn- und Sportgemeinschaft 1899 Hoffenheim e.V., or simply TSG 1899 Hoffenheim or just Hoffenheim ([teː ʔɛs ɡeː ˈʔaxt͡seːnˈhʊndɐt ˈnɔʏ̯nʔʊntˈnɔʏ̯nt͡sɪç ˈhɔfn̩haɪ̯m]) is a German professional football club based in Hoffenheim, a village of Sinsheim municipality, Baden-Württemberg.

Originally founded in 1899 as a gymnastics club, Hoffenheim came into being in its modern form in 1945. A fifth division side in 2000, the club rapidly advanced through the German football league system with the financial backing of alumnus and software mogul Dietmar Hopp, and in 2008 Hoffenheim was promoted to the top tier Bundesliga. In the 2017–18 season, Hoffenheim finished third in the Bundesliga (its best to date), qualifying for the UEFA Champions League group stage for the first time.

Since 2009, Hoffenheim has played its home games at the Rhein-Neckar-Arena (currently known as PreZero Arena), having previously played at the Dietmar-Hopp-Stadion from 1999.

The modern-day club was formed in 1945, when gymnastics club Turnverein Hoffenheim (founded 1 July 1899) and football club Fußballverein Hoffenheim (founded 1921) merged. At the beginning of the 1990s, the club was an obscure local amateur side playing in the eighth division Baden-Württemberg A-Liga. They steadily improved and by 1996 were competing in the Verbandsliga Nordbaden (V).